Ipamorelin
★ 92Ipamorelin
Clean GH pulse without cortisol elevation
Muscle GrowthAbout
A selective ghrelin receptor agonist that stimulates growth hormone release without raising cortisol or prolactin.
Mechanism
Binds GHS-R1a receptors in the pituitary and triggers a clean GH pulse.
Dosage
beginner
- Amount
- 100 mcg
- Frequency
- 1x per day before sleep
- Route
- SubQ
- Duration
- 8-12 weeks
standard
- Amount
- 200-300 mcg
- Frequency
- 1-2x per day (evening + morning)
- Route
- SubQ
- Duration
- 12-16 weeks
advanced
- Amount
- 300 mcg
- Frequency
- 3x per day (morning, pre-workout, evening)
- Route
- SubQ
- Duration
- 12-16 weeks with breaks
On an empty stomach, 30-60 min before food or sleep. Important: no food for 30-60 min after.
12-16 weeks on, 4 weeks off to avoid receptor desensitization
Reconstitution & Storage
Often blended with CJC-1295 in the same syringe.
Dosing reference — units to draw
Concentration = peptide mass ÷ bacteriostatic water; units to draw = dose volume (mL) × 100 on a U-100 insulin syringe. Each vial size below is shown at 2 mL, with the units to draw for a typical 200–300 mcg dose.
| Vial | BAC water | Concentration | Units to draw |
|---|---|---|---|
| 10 mg | 2 mL | 5000 mcg/mL | 4–6 units |
Lyophilized: freezer. Reconstituted: 2-8°C, 28 days.
Benefits
- • Natural GH elevation
- • Improved sleep
- • Muscle building
- • Fat loss
- • Improved skin and hair quality
- • No cortisol elevation
Side effects
- • Tingling in hands (transient)
- • Vivid dreams
- • Transient headache
- • Mild hunger
Contraindications
- • Active cancer (hard contraindication)
- • Pregnancy and breastfeeding
- • Diabetes (monitor blood glucose)
- • Pituitary tumors
Gender notes
Men
Common dose 200-300 mcg. Indirectly supports testosterone optimization.
Women
Start at 100-150 mcg. Hormone sensitivity is higher. Excellent for aging and skin health.
Research
- Raun H et al: Ipamorelin selective GH release without ACTH/cortisol ↗
Key study showing ipamorelin stimulates GH without elevating cortisol or ACTH.
European Journal of Endocrinology · 1998
- Sinha DK et al: Clinical applications of GH secretagogues ↗
Review of GH secretagogues in clinical use.
Translational Andrology and Urology · 2020
Stacks well with
Ipamorelin FAQ
How do you reconstitute Ipamorelin?
Add 2 mL of bacteriostatic water to a 10 mg vial of Ipamorelin, which gives a concentration of 5000 mcg/mL. Inject the water slowly down the vial wall and swirl gently — never shake.
What is a typical Ipamorelin dose?
A typical research dose of Ipamorelin is 200–300 mcg, 1-2x per day (evening + morning). This is educational information, not medical advice.
How many units of Ipamorelin do I draw?
From a 10 mg vial reconstituted with 2 mL of bacteriostatic water, draw 4–6 units on a U-100 insulin syringe for a 200–300 mcg dose.
Track Ipamorelin doses in the app
Built-in reconstitution calculator, dose log, and reminders. Free on Android.
Get on Google PlayEducational use only. Not medical advice. Many peptides shown are not FDA-approved and remain research compounds. Always consult a qualified healthcare provider.