Ipamorelin

★ 92

Ipamorelin

Clean GH pulse without cortisol elevation

Muscle Growth

Half-life

~2 hours

Route

SubQ

Cycle

12-16 weeks on,

Status

Phase II trials completed

About

A selective ghrelin receptor agonist that stimulates growth hormone release without raising cortisol or prolactin.

Mechanism

Binds GHS-R1a receptors in the pituitary and triggers a clean GH pulse.

Dosage

beginner

Amount: 100 mcg
Frequency: 1x per day before sleep
Route: SubQ
Duration: 8-12 weeks

standard

Amount: 200-300 mcg
Frequency: 1-2x per day (evening + morning)
Route: SubQ
Duration: 12-16 weeks

advanced

Amount: 300 mcg
Frequency: 3x per day (morning, pre-workout, evening)
Route: SubQ
Duration: 12-16 weeks with breaks

Timing

On an empty stomach, 30-60 min before food or sleep. Important: no food for 30-60 min after.

Cycle structure

12-16 weeks on, 4 weeks off to avoid receptor desensitization

Reconstitution & Storage

5 mg + 2 mL → 2500 mcg/mL

Often blended with CJC-1295 in the same syringe.

Lyophilized: freezer. Reconstituted: 2-8°C, 28 days.

Benefits

• Natural GH elevation
• Improved sleep
• Muscle building
• Fat loss
• Improved skin and hair quality
• No cortisol elevation

Side effects

• Tingling in hands (transient)
• Vivid dreams
• Transient headache
• Mild hunger

Contraindications

• Active cancer (hard contraindication)
• Pregnancy and breastfeeding
• Diabetes (monitor blood glucose)
• Pituitary tumors

Gender notes

Men

Common dose 200-300 mcg. Indirectly supports testosterone optimization.

Women

Start at 100-150 mcg. Hormone sensitivity is higher. Excellent for aging and skin health.

Research

Raun H et al: Ipamorelin selective GH release without ACTH/cortisol ↗
Key study showing ipamorelin stimulates GH without elevating cortisol or ACTH.

European Journal of Endocrinology · 1998
Sinha DK et al: Clinical applications of GH secretagogues ↗
Review of GH secretagogues in clinical use.

Translational Andrology and Urology · 2020

Stacks well with

CJC-1295 BPC-157 TESAMORELIN

Track Ipamorelin doses in the app

Built-in reconstitution calculator, dose log, and reminders. Free on Android.

Get on Google Play

Educational use only. Not medical advice. Many peptides shown are not FDA-approved and remain research compounds. Always consult a qualified healthcare provider.