Peptora Get app
← All peptides

Kisspeptin-10

★ 68

Kisspeptin-10 (Metastin 45-54)

GnRH stimulator — HPG axis activator

Sexual Health
Half-life
~4 minutes (very short!)
Route
Subcutaneous (SubQ)
Cycle
4-12 week cycles,
Status
Clinical trials underway for HSDD and hypogonadism

About

A 10-amino-acid peptide that activates Kiss1R receptors in the hypothalamus, the strongest natural activator of GnRH. Studied for hypogonadism and low testosterone.

Mechanism

Binds Kiss1R receptors on GnRH neurons, triggering an LH and FSH pulse and then testosterone or estradiol release.

Dosage

beginner

Amount
50 mcg
Frequency
1x per day
Route
Subcutaneous (SubQ)
Duration
4-6 weeks

standard

Amount
100 mcg
Frequency
1-2x per day
Route
Subcutaneous (SubQ)
Duration
6-8 weeks

advanced

Amount
200 mcg
Frequency
2x per day
Route
Subcutaneous (SubQ)
Duration
8-12 weeks
Timing

Best in the morning when natural hormone pulses are activating.

Cycle structure

4-12 week cycles, with at least a 4-week break (to avoid desensitization).

Reconstitution & Storage

5 mg + 5 mL → 1 mg/mL

A large bac volume yields convenient small doses. Very fragile — the peptide degrades quickly.

Lyophilized: refrigerated. After reconstitution: 2-8°C, 7-14 days (shorter than most).

Benefits

  • • Naturally raises LH and FSH
  • • Improved libido (both sexes)
  • • Raises testosterone (men)
  • • Possible fertility boost
  • • Gentler than HCG (no desensitization)

Side effects

  • • Headache
  • • Flushing and warmth
  • • Rare: nausea
  • • Well tolerated at low doses

Contraindications

  • • Hormone-sensitive cancers
  • • Pregnancy
  • • Pituitary tumor
  • • Use of tamoxifen or aromatase inhibitors

Gender notes

Men

Raises LH → testosterone. Popular as an HCG alternative.

Women

Studied for HSDD and fertility — depends on the cycle phase.

Research

Stacks well with

PT-141

Track Kisspeptin-10 doses in the app

Built-in reconstitution calculator, dose log, and reminders. Free on Android.

Get on Google Play

Educational use only. Not medical advice. Many peptides shown are not FDA-approved and remain research compounds. Always consult a qualified healthcare provider.