Kisspeptin-10

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Kisspeptin-10 (Metastin 45-54)

GnRH stimulator — HPG axis activator

Sexual Health

Half-life

~4 minutes (very short!)

Route

Subcutaneous (SubQ)

Cycle

4-12 week cycles,

Status

Clinical trials underway for HSDD and hypogonadism

About

A 10-amino-acid peptide that activates Kiss1R receptors in the hypothalamus, the strongest natural activator of GnRH. Studied for hypogonadism and low testosterone.

Mechanism

Binds Kiss1R receptors on GnRH neurons, triggering an LH and FSH pulse and then testosterone or estradiol release.

Dosage

beginner

Amount: 50 mcg
Frequency: 1x per day
Route: Subcutaneous (SubQ)
Duration: 4-6 weeks

standard

Amount: 100 mcg
Frequency: 1-2x per day
Route: Subcutaneous (SubQ)
Duration: 6-8 weeks

advanced

Amount: 200 mcg
Frequency: 2x per day
Route: Subcutaneous (SubQ)
Duration: 8-12 weeks

Timing

Best in the morning when natural hormone pulses are activating.

Cycle structure

4-12 week cycles, with at least a 4-week break (to avoid desensitization).

Reconstitution & Storage

5 mg + 2 mL → 2500 mcg/mL

A large bac volume yields convenient small doses. Very fragile — the peptide degrades quickly.

Dosing reference — units to draw

Concentration = peptide mass ÷ bacteriostatic water; units to draw = dose volume (mL) × 100 on a U-100 insulin syringe. Each vial size below is shown at 2 mL, with the units to draw for a typical 100–200 mcg dose.

Kisspeptin-10 reconstitution: vial size, bacteriostatic water, resulting concentration, and units to draw on a U-100 insulin syringe for a typical dose.
Vial	BAC water	Concentration	Units to draw
5 mg	2 mL	2500 mcg/mL	4–8 units
10 mg	2 mL	5000 mcg/mL	2–4 units

Open Kisspeptin-10 in the reconstitution calculator →

Lyophilized: refrigerated. After reconstitution: 2-8°C, 7-14 days (shorter than most).

Benefits

• Naturally raises LH and FSH
• Improved libido (both sexes)
• Raises testosterone (men)
• Possible fertility boost
• Gentler than HCG (no desensitization)

Side effects

• Headache
• Flushing and warmth
• Rare: nausea
• Well tolerated at low doses

Contraindications

• Hormone-sensitive cancers
• Pregnancy
• Pituitary tumor
• Use of tamoxifen or aromatase inhibitors

Gender notes

Men

Raises LH → testosterone. Popular as an HCG alternative.

Women

Studied for HSDD and fertility — depends on the cycle phase.

Research

Comninos et al: Kisspeptin in HSDD women ↗
Clinical trial in women with low sexual desire — improved arousal and response.

JCI Insight · 2020
George et al: Kisspeptin in male testosterone ↗
In men — activates LH naturally, stronger than a GnRH analog.

J Clin Endocrinol Metab · 2011

Stacks well with

PT-141

Kisspeptin-10 FAQ

How do you reconstitute Kisspeptin-10?

Add 2 mL of bacteriostatic water to a 5 mg vial of Kisspeptin-10, which gives a concentration of 2500 mcg/mL. Inject the water slowly down the vial wall and swirl gently — never shake.

What is a typical Kisspeptin-10 dose?

A typical research dose of Kisspeptin-10 is 100–200 mcg, 1-2x per day. This is educational information, not medical advice.

How many units of Kisspeptin-10 do I draw?

From a 5 mg vial reconstituted with 2 mL of bacteriostatic water, draw 4–8 units on a U-100 insulin syringe for a 100–200 mcg dose.

Track Kisspeptin-10 doses in the app

Built-in reconstitution calculator, dose log, and reminders. Free on Android.

Get on Google Play

Educational use only. Not medical advice. Many peptides shown are not FDA-approved and remain research compounds. Always consult a qualified healthcare provider.