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PT-141

★ 78 FDA approved

Bremelanotide (Vyleesi)

Sexual desire for both women and men

Sexual Health
Half-life
~2 hours
Route
SubQ
Cycle
On-demand. Not daily.
Status
FDA approved for HSDD (women). Off-label for men.

About

A melanocortin receptor agonist that acts on the brain to increase sexual desire — not the vascular system (unlike Viagra). FDA approved 2019.

Mechanism

Activates MC3R and MC4R receptors in the dopamine pathways of the brain that govern libido and arousal.

Dosage

beginner

Amount
500-750 mcg
Frequency
On-demand, 45 min before activity
Route
SubQ
Duration
On-demand

standard

Amount
1.0-1.75 mg
Frequency
On-demand, max 8x per month
Route
SubQ
Duration
On-demand

advanced

Amount
1.75 mg
Frequency
On-demand, max 8 doses/month
Route
SubQ
Duration
On-demand
Timing

45 min - 4 hours before sex. Not on an empty stomach (worst nausea).

Cycle structure

On-demand. Not daily.

Reconstitution & Storage

5 mg + 1 mL → 5000 mcg/mL

Store refrigerated after reconstitution.

Dosing reference — units to draw

Concentration = peptide mass ÷ bacteriostatic water; units to draw = dose volume (mL) × 100 on a U-100 insulin syringe. Each vial size below is shown at 1 mL, with the units to draw for a typical 500–1000 mcg dose.

PT-141 reconstitution: vial size, bacteriostatic water, resulting concentration, and units to draw on a U-100 insulin syringe for a typical dose.
Vial BAC water Concentration Units to draw
5 mg 1 mL 5000 mcg/mL 10–20 units
10 mg 1 mL 10000 mcg/mL 5–10 units

Open PT-141 in the reconstitution calculator →

Lyophilized: cool. Reconstituted: 2-8°C, 4 weeks.

Benefits

  • • Increases sexual desire (both sexes)
  • • Helps with ED when PDE5 inhibitors do not work
  • • Acts on the brain, not the vasculature
  • • No need for visual stimulation

Side effects

  • • Nausea (very common, 40%+)
  • • Facial flushing
  • • Transient blood pressure increase
  • • Headache
  • • Skin darkening with repeated use (rare)

Contraindications

  • • Hypertension (uncontrolled)
  • • Cardiovascular disease
  • • Pregnancy

Gender notes

Men

Off-label use. 1-1.75 mg common. Sometimes stacked with tadalafil.

Women

FDA approved for premenopausal HSDD. 1.75 mg standard. No post-menopausal indication yet.

Research

Stacks well with

KISSPEPTIN-10

PT-141 FAQ

How do you reconstitute PT-141?

Add 1 mL of bacteriostatic water to a 5 mg vial of PT-141, which gives a concentration of 5000 mcg/mL. Inject the water slowly down the vial wall and swirl gently — never shake.

What is a typical PT-141 dose?

A typical research dose of PT-141 is 500–1000 mcg, on-demand, max 8x per month. This is educational information, not medical advice.

How many units of PT-141 do I draw?

From a 5 mg vial reconstituted with 1 mL of bacteriostatic water, draw 10–20 units on a U-100 insulin syringe for a 500–1000 mcg dose.

Track PT-141 doses in the app

Built-in reconstitution calculator, dose log, and reminders. Free on Android.

Get on Google Play

Educational use only. Not medical advice. Many peptides shown are not FDA-approved and remain research compounds. Always consult a qualified healthcare provider.