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KPV

★ 65

Lysine-Proline-Valine (α-MSH 11-13)

Anti-inflammatory tripeptide derived from α-MSH

Healing & Recovery
Half-life
Short (minutes SubQ, longer oral)
Route
Subcutaneous (SubQ) or oral
Cycle
4-12 week cycles
Status
Strong preclinical

About

A three-amino-acid peptide derived from the C-terminus of α-MSH (melanocyte stimulating hormone). Strong anti-inflammatory effects without melanocortin receptor activation.

Mechanism

Inhibits the NF-κB pathway, reducing TNF-α, IL-1β and IL-6. Strong effects in gut-related inflammation.

Dosage

beginner

Amount
200 mcg
Frequency
1x per day
Route
Subcutaneous (SubQ) or oral
Duration
4-8 weeks

standard

Amount
500 mcg
Frequency
1-2x per day
Route
Subcutaneous (SubQ) or oral
Duration
6-12 weeks

advanced

Amount
1000 mcg
Frequency
2x per day
Route
Subcutaneous (SubQ) or oral
Duration
8-12 weeks
Timing

Timing matters little — morning or evening is fine.

Cycle structure

4-12 week cycles with 2-4 week breaks.

Reconstitution & Storage

5 mg + 2 mL → 2.5 mg/mL

Stable peptide. Can be taken orally with reduced absorption.

Lyophilized: refrigerated, months. After reconstitution: 2-8°C, 28 days.

Benefits

  • • Reduces systemic inflammation
  • • Helps with IBD and leaky gut
  • • Skin conditions (acne, psoriasis)
  • • Anti-microbial
  • • Well tolerated

Side effects

  • • Very well tolerated
  • • Rare: injection-site irritation
  • • No known serious side effects

Contraindications

  • • Pregnancy (limited data)
  • • History of melanoma (caution — α-MSH derivative)

Gender notes

Men

Same dose as general protocol.

Women

Same dose.

Research

Stacks well with

BPC-157 TB-500

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Educational use only. Not medical advice. Many peptides shown are not FDA-approved and remain research compounds. Always consult a qualified healthcare provider.