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LL-37

★ 60

LL-37 (Cathelicidin antimicrobial peptide)

The only human cathelicidin — antimicrobial + healing

Healing & Recovery
Half-life
~30 minutes (SubQ)
Route
Subcutaneous (SubQ)
Cycle
2-8 week cycles,
Status
Phase 1-2 trials for wound healing and chronic infections

About

A 37-amino-acid peptide, the only human cathelicidin. Strong antimicrobial effects against bacteria, fungi, viruses and biofilms. Also immune-modulating and wound-healing.

Mechanism

Disrupts pathogen cell membranes, modulates immune response, increases angiogenesis and tissue repair.

Dosage

beginner

Amount
100 mcg
Frequency
1x per day
Route
Subcutaneous (SubQ) or topical
Duration
2-4 weeks

standard

Amount
200 mcg
Frequency
1x per day
Route
Subcutaneous (SubQ)
Duration
4-6 weeks

advanced

Amount
500 mcg
Frequency
1-2x per day
Route
Subcutaneous (SubQ) or perilesional
Duration
6-8 weeks
Timing

Timing matters little. Short cycles for active infection, longer for chronic.

Cycle structure

2-8 week cycles, with a 4-week break between.

Reconstitution & Storage

5 mg + 2 mL → 2500 mcg/mL

Slightly fragile — refrigerate immediately after reconstitution.

Dosing reference — units to draw

Concentration = peptide mass ÷ bacteriostatic water; units to draw = dose volume (mL) × 100 on a U-100 insulin syringe. Each vial size below is shown at 2 mL, with the units to draw for a typical 250–1000 mcg dose.

LL-37 reconstitution: vial size, bacteriostatic water, resulting concentration, and units to draw on a U-100 insulin syringe for a typical dose.
Vial BAC water Concentration Units to draw
5 mg 2 mL 2500 mcg/mL 10–40 units
10 mg 2 mL 5000 mcg/mL 5–20 units

Open LL-37 in the reconstitution calculator →

Lyophilized: freezer or refrigerator. After reconstitution: 2-8°C, 14 days.

Benefits

  • • Strong antimicrobial (bacteria, fungi, viruses)
  • • Breaks down biofilms
  • • Accelerated wound healing
  • • Immune modulation
  • • Potentially anti-cancer (preliminary)

Side effects

  • • Injection-site irritation (common)
  • • Redness and mild warmth
  • • Rare: mild allergic reaction
  • • Well tolerated at low doses

Contraindications

  • • Pregnancy (limited data)
  • • Autoimmune disease (caution)
  • • History of cytokine storm

Gender notes

Men

Same dose as general protocol.

Women

Same dose. Popular for chronic UTI and recurrent infections.

Research

Stacks well with

BPC-157 THYMOSIN-ALPHA-1

LL-37 FAQ

How do you reconstitute LL-37?

Add 2 mL of bacteriostatic water to a 5 mg vial of LL-37, which gives a concentration of 2500 mcg/mL. Inject the water slowly down the vial wall and swirl gently — never shake.

What is a typical LL-37 dose?

A typical research dose of LL-37 is 250–1000 mcg, 1x per day. This is educational information, not medical advice.

How many units of LL-37 do I draw?

From a 5 mg vial reconstituted with 2 mL of bacteriostatic water, draw 10–40 units on a U-100 insulin syringe for a 250–1000 mcg dose.

Track LL-37 doses in the app

Built-in reconstitution calculator, dose log, and reminders. Free on Android.

Get on Google Play

Educational use only. Not medical advice. Many peptides shown are not FDA-approved and remain research compounds. Always consult a qualified healthcare provider.