Peptora
← All peptides

MOTS-c

★ 78

Mitochondrial-derived peptide MOTS-c

Mitochondrial peptide — metabolic switch

Longevity
Half-life
Short, but effects last 24+ hours
Route
SubQ
Cycle
6-12 weeks on,
Status
Strong preclinical

About

A naturally occurring peptide encoded by mitochondrial DNA. Increases AMPK activity, improves glucose tolerance and metabolic flexibility.

Mechanism

Activates the AMPK pathway, promoting fat oxidation, glucose utilization, and mitochondrial health.

Dosage

beginner

Amount
5 mg
Frequency
3x per week
Route
SubQ
Duration
4-6 weeks

standard

Amount
10 mg
Frequency
3x per week
Route
SubQ
Duration
6-8 weeks

advanced

Amount
10-15 mg
Frequency
3-5x per week
Route
SubQ
Duration
8-12 weeks with a 4-week break
Timing

Pre-workout or in the morning on an empty stomach.

Cycle structure

6-12 weeks on, 4 weeks off.

Reconstitution & Storage

10 mg + 1 mL → 10 mg/mL

Relatively expensive — measure precisely.

Dosing reference — units to draw

Concentration = peptide mass ÷ bacteriostatic water; units to draw = dose volume (mL) × 100 on a U-100 insulin syringe. Each vial size below is shown at 1 mL, with the units to draw for a typical 5–10 mg dose.

MOTS-c reconstitution: vial size, bacteriostatic water, resulting concentration, and units to draw on a U-100 insulin syringe for a typical dose.
Vial BAC water Concentration Units to draw
10 mg 1 mL 10 mg/mL 50–100 units

Open MOTS-c in the reconstitution calculator →

Lyophilized: freezer. Reconstituted: 2-8°C, 14 days.

Benefits

  • • Improved mitochondrial function
  • • Increased insulin sensitivity
  • • Fat loss
  • • Improved energy
  • • Slower aging (animal data)
  • • Improved athletic performance

Side effects

  • • Generally very well tolerated
  • • Rare: mild fatigue at first

Contraindications

  • • Pregnancy (no research)
  • • Type 1 diabetes (caution — monitor blood glucose)

Gender notes

Men

Same dose. Popular for performance.

Women

Same dose. Especially useful in menopause (metabolic slowdown).

Research

Stacks well with

BPC-157 IPAMORELIN TESAMORELIN

MOTS-c FAQ

How do you reconstitute MOTS-c?

Add 1 mL of bacteriostatic water to a 10 mg vial of MOTS-c, which gives a concentration of 10 mg/mL. Inject the water slowly down the vial wall and swirl gently — never shake.

What is a typical MOTS-c dose?

A typical research dose of MOTS-c is 5–10 mg, 3x per week. This is educational information, not medical advice.

How many units of MOTS-c do I draw?

From a 10 mg vial reconstituted with 1 mL of bacteriostatic water, draw 50–100 units on a U-100 insulin syringe for a 5–10 mg dose.

Track MOTS-c doses in the app

Built-in reconstitution calculator, dose log, and reminders. Free on Android.

Get on Google Play

Educational use only. Not medical advice. Many peptides shown are not FDA-approved and remain research compounds. Always consult a qualified healthcare provider.