Sermorelin

★ 75 FDA approved

Sermorelin Acetate (GRF 1-29)

Classic GHRH analog — more natural GH pulse

Muscle Growth

Half-life

~10-20 minutes

Route

Subcutaneous (SubQ)

Cycle

3-6 month cycles

Status

FDA approved for pediatric GH deficiency

About

A 29-amino-acid GHRH analog, FDA approved since 1990 as Geref. The short half-life delivers a more natural GH pulse than CJC-1295. Popular in US anti-aging clinics.

Mechanism

Activates pituitary GHRH receptors, increasing endogenous GH production without overstimulation.

Dosage

beginner

Amount: 100 mcg
Frequency: 1x per day before sleep
Route: Subcutaneous (SubQ)
Duration: 8-12 weeks

standard

Amount: 200-300 mcg
Frequency: 1x per day before sleep
Route: Subcutaneous (SubQ)
Duration: 12-24 weeks

advanced

Amount: 300-500 mcg
Frequency: 1-2x per day (evening + morning)
Route: Subcutaneous (SubQ)
Duration: 16-24 weeks

Timing

Best before sleep (at least 2 hours after food) — the natural GH pulse is strongest then.

Cycle structure

3-6 month cycles with 4-8 week breaks in between.

Reconstitution & Storage

5 mg + 1 mL → 5 mg/mL

Very fragile — handle gently, refrigerate immediately after reconstitution.

Dosing reference — units to draw

Concentration = peptide mass ÷ bacteriostatic water; units to draw = dose volume (mL) × 100 on a U-100 insulin syringe. Each vial size below is shown at 1 mL, with the units to draw for a typical 0.5–2 mg dose.

Sermorelin reconstitution: vial size, bacteriostatic water, resulting concentration, and units to draw on a U-100 insulin syringe for a typical dose.
Vial	BAC water	Concentration	Units to draw
5 mg	1 mL	5 mg/mL	10–40 units
10 mg	1 mL	10 mg/mL	5–20 units

Open Sermorelin in the reconstitution calculator →

Lyophilized: refrigerated, 24+ months. Reconstituted: 2-8°C, 14 days (shorter than CJC-1295).

Benefits

• More natural GH pulse than CJC-1295
• Improved sleep depth
• Increased muscle mass
• Improved skin and hair
• Milder side-effect profile

Side effects

• Injection-site irritation
• Headache (fresh dose)
• Mild sleep disturbance in the first days
• Possible nausea

Contraindications

• Active cancer
• Pregnancy and breastfeeding
• Diabetic retinopathy (consult physician)
• Pituitary tumor

Gender notes

Men

Same dose. Popular after age 35.

Women

Same dose. Popular for skin and hair.

Research

Walker et al: Sermorelin in adult GH deficiency ↗
Clinical trials demonstrating efficacy of sermorelin in GH deficiency.

Aging Male · 2006
Khorram et al: Sermorelin in older adults ↗
16-week sermorelin treatment in 60-71 year olds: elevated GH and IGF-1.

J Clin Endocrinol Metab · 1997

Stacks well with

IPAMORELIN GHK-CU

Sermorelin FAQ

How do you reconstitute Sermorelin?

Add 1 mL of bacteriostatic water to a 5 mg vial of Sermorelin, which gives a concentration of 5 mg/mL. Inject the water slowly down the vial wall and swirl gently — never shake.

What is a typical Sermorelin dose?

A typical research dose of Sermorelin is 0.5–2 mg, 1x per day before sleep. This is educational information, not medical advice.

How many units of Sermorelin do I draw?

From a 5 mg vial reconstituted with 1 mL of bacteriostatic water, draw 10–40 units on a U-100 insulin syringe for a 0.5–2 mg dose.

Track Sermorelin doses in the app

Built-in reconstitution calculator, dose log, and reminders. Free on Android.

Get on Google Play

Educational use only. Not medical advice. Many peptides shown are not FDA-approved and remain research compounds. Always consult a qualified healthcare provider.