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SS-31

★ 70

SS-31 / Elamipretide (Bendavia)

Mitochondria-protective peptide

Longevity
Half-life
~2-3 hours (SubQ)
Route
Subcutaneous (SubQ)
Cycle
8-16 week cycles,
Status
Phase 3 (Stealth BioTherapeutics)

About

A small peptide that binds the inner mitochondrial membrane and reduces cardiolipin oxidation. Phase 3 trials in primary mitochondrial myopathy and heart failure.

Mechanism

Binds cardiolipin in the inner mitochondrial membrane, protects the electron transport chain, reduces ROS.

Dosage

beginner

Amount
20 mg
Frequency
1x per day
Route
Subcutaneous (SubQ)
Duration
4-8 weeks

standard

Amount
40 mg
Frequency
1x per day
Route
Subcutaneous (SubQ)
Duration
8-12 weeks

advanced

Amount
60 mg
Frequency
1x per day
Route
Subcutaneous (SubQ)
Duration
12-16 weeks
Timing

Best in the morning — energy-related effects.

Cycle structure

8-16 week cycles, with a 4-week break.

Reconstitution & Storage

10 mg + 1 mL → 10 mg/mL

Larger vials require larger bac volumes due to mg quantity.

Dosing reference — units to draw

Concentration = peptide mass ÷ bacteriostatic water; units to draw = dose volume (mL) × 100 on a U-100 insulin syringe. Each vial size below is shown at 1 mL, with the units to draw for a typical 5–5 mg dose.

SS-31 reconstitution: vial size, bacteriostatic water, resulting concentration, and units to draw on a U-100 insulin syringe for a typical dose.
Vial BAC water Concentration Units to draw
10 mg 1 mL 10 mg/mL 50–50 units
15 mg 1 mL 15 mg/mL 33.5–33.5 units

Open SS-31 in the reconstitution calculator →

Lyophilized: refrigerated. Reconstituted: 2-8°C, 30 days.

Benefits

  • • Protects mitochondria
  • • Improved energy and endurance
  • • Cardioprotective effects
  • • Possibly anti-aging via mitochondrial biogenesis
  • • Reduced muscle fatigue

Side effects

  • • Injection-site irritation
  • • Rare: headache
  • • Well tolerated in clinical trials

Contraindications

  • • Limited pregnancy data
  • • Drug interactions not yet fully studied

Gender notes

Men

Same dose as general protocol.

Women

Same dose.

Research

Stacks well with

MOTS-C EPITALON

SS-31 FAQ

How do you reconstitute SS-31?

Add 1 mL of bacteriostatic water to a 10 mg vial of SS-31, which gives a concentration of 10 mg/mL. Inject the water slowly down the vial wall and swirl gently — never shake.

What is a typical SS-31 dose?

A typical research dose of SS-31 is 5–5 mg, 1x per day. This is educational information, not medical advice.

How many units of SS-31 do I draw?

From a 10 mg vial reconstituted with 1 mL of bacteriostatic water, draw 50–50 units on a U-100 insulin syringe for a 5–5 mg dose.

Track SS-31 doses in the app

Built-in reconstitution calculator, dose log, and reminders. Free on Android.

Get on Google Play

Educational use only. Not medical advice. Many peptides shown are not FDA-approved and remain research compounds. Always consult a qualified healthcare provider.