Humanin

★ 65

Humanin (HN, mitochondrial-derived peptide)

Mitochondrial peptide — neuroprotective + longevity

Longevity

Half-life

~30 minutes (SubQ)

Route

SubQ

Cycle

8-12 week cycles,

Status

Strong preclinical (rodent

About

A 24-amino-acid mitochondrial-derived peptide. Sister molecule to MOTS-c. Strong preclinical data for Alzheimer protection, ischemia recovery, and cellular longevity.

Mechanism

Binds the IGFBP-3 / FPR2L receptor complex; activates JAK/STAT3 survival signaling, inhibits Bax-mediated apoptosis, and reduces ER stress.

Dosage

beginner

Amount: 5 mg
Frequency: 1x per day
Route: Subcutaneous (SubQ)
Duration: 4-8 weeks

standard

Amount: 5-10 mg
Frequency: 1x per day
Route: SubQ
Duration: 8-12 weeks

advanced

Amount: 10-15 mg
Frequency: 1x per day
Route: SubQ
Duration: 12 weeks with a 4-week break

Timing

Morning preferred for cognitive effects; any time is fine.

Cycle structure

8-12 week cycles, 4 weeks off.

Reconstitution & Storage

10 mg + 2 mL → 5 mg/mL

Stable peptide. Standard reconstitution protocol.

Lyophilized: refrigerated. Reconstituted: 2-8°C, 28 days.

Benefits

• Neuroprotection (Alzheimer models)
• Improved insulin sensitivity
• Reduced cellular apoptosis
• Cardioprotective effects
• Mitochondrial biogenesis

Side effects

• Generally very well tolerated
• Rare: mild fatigue at start
• No serious side effects reported in animal studies

Contraindications

• Pregnancy (no research)
• Active cancer (caution — survival signaling could theoretically protect tumor cells)

Gender notes

Men

Same dose. Popular for cognitive longevity stacks.

Women

Same dose. Endogenous humanin levels decline with menopause — supplementation may have outsized benefit.

Research

Hashimoto Y et al: Humanin protects against Alzheimer-related cell death ↗
Landmark 2001 study discovering humanin via screening for Alzheimer-protective peptides.

Proceedings of the National Academy of Sciences · 2001
Yen K et al: Humanin levels decline with age and disease ↗
Circulating humanin drops significantly with aging and accelerates in Alzheimer patients.

GeroScience · 2020

Stacks well with

MOTS-C EPITALON SS-31

Track Humanin doses in the app

Built-in reconstitution calculator, dose log, and reminders. Free on Android.

Get on Google Play

Educational use only. Not medical advice. Many peptides shown are not FDA-approved and remain research compounds. Always consult a qualified healthcare provider.