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Klotho

★ 58

α-Klotho (soluble fragment)

Anti-aging protein — overexpression extends mouse lifespan ~30%

Longevity
Half-life
Short circulating (~30 min) but effects sustained via gene expression changes.
Route
SubQ
Cycle
Long cycles tolerated.
Status
Highly experimental as therapy. Strong genetic / preclinical data; no FDA-approved human peptide therapy yet. Compounding pharmacies offer research-grade.

About

Soluble α-klotho is a circulating fragment of the Klotho protein, named after the Greek fate who spins the thread of life. Mice engineered to overexpress klotho live 30% longer; klotho-deficient mice age prematurely.

Mechanism

Co-receptor for FGF23 (phosphate homeostasis); inhibits insulin/IGF-1 signaling (longevity pathway); enhances antioxidant FOXO transcription; modulates Wnt and TGF-β signaling.

Dosage

beginner

Amount
100 mcg
Frequency
1x per week
Route
Subcutaneous (SubQ)
Duration
12 weeks (one cycle)

standard

Amount
200-400 mcg
Frequency
1-2x per week
Route
SubQ
Duration
12-24 weeks

advanced

Amount
500 mcg
Frequency
2x per week
Route
SubQ
Duration
24 weeks with a 4-8 week break
Timing

Any time; weekly cadence makes timing less important.

Cycle structure

Long cycles tolerated. Conservative protocol: 12-24 weeks on, 8 weeks off.

Reconstitution & Storage

1 mg + 1 mL → 1 mg/mL

Expensive — measure precisely. Sensitive to heat; keep cold throughout.

Lyophilized: -20°C freezer. Reconstituted: 2-8°C, 14 days.

Benefits

  • • Possible lifespan extension (animal data)
  • • Cognitive protection (Alzheimer models)
  • • Cardiovascular protection
  • • Kidney protection
  • • Bone density maintenance
  • • Insulin/IGF-1 axis modulation

Side effects

  • • Limited human data — side effects largely unknown
  • • Theoretical: altered phosphate metabolism (FGF23 co-receptor effects)
  • • Animal studies show good tolerability

Contraindications

  • • Pregnancy and breastfeeding
  • • Chronic kidney disease (phosphate metabolism interaction)
  • • Hyperphosphatemia
  • • Active cancer (insufficient data on tumor signaling impact)

Gender notes

Men

Same dose. Popular in advanced longevity stacks.

Women

Same dose. Klotho levels drop with menopause — supplementation hypothesized to support bone + cognitive health.

Research

Stacks well with

EPITALON MOTS-C HUMANIN SS-31

Track Klotho doses in the app

Built-in reconstitution calculator, dose log, and reminders. Free on Android.

Get on Google Play

Educational use only. Not medical advice. Many peptides shown are not FDA-approved and remain research compounds. Always consult a qualified healthcare provider.